Human Gene PPP1R10 (uc011gte.3) Description and Page Index
  Description: Homo sapiens protein phosphatase 1, regulatory subunit 10 (PPP1R10), transcript variant 1, mRNA.
RefSeq Summary (NM_002714): This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,916,249-1,933,156 Size: 16,908 Total Exon Count: 20 Strand: -
Coding Region
   Position: chr6_mann_hap4:1,917,398-1,925,793 Size: 8,396 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: PP1RA_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 1 regulatory subunit 10; AltName: Full=MHC class I region proline-rich protein CAT53; AltName: Full=PP1-binding protein of 114 kDa; AltName: Full=Phosphatase 1 nuclear targeting subunit; AltName: Full=Protein FB19; AltName: Full=p99;
FUNCTION: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).
SUBUNIT: Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).
SUBCELLULAR LOCATION: Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity).
TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
PTM: Phosphorylated on Ser-398 and Thr-400 by PKA within the region necessary for interaction with PPP1CA (By similarity).
SIMILARITY: Contains 1 C3H1-type zinc finger.
SIMILARITY: Contains 1 TFIIS N-terminal domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: PPP1R10
CDC HuGE Published Literature: PPP1R10
Positive Disease Associations: Behcet Syndrome
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -190.91616-0.310 Picture PostScript Text
3' UTR -402.221149-0.350 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003617 - TFIIS/CRSP70_N_sub
IPR017923 - TFIIS_N
IPR000571 - Znf_CCCH

Pfam Domains:
PF00642 - Zinc finger C-x8-C-x5-C-x3-H type (and similar)

SCOP Domains:
47676 - Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
90229 - CCCH zinc finger

ModBase Predicted Comparative 3D Structure on Q96QC0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
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-  Descriptions from all associated GenBank mRNAs
  Y13247 - Homo sapiens fb19 mRNA.
AJ544537 - Homo sapiens mRNA for protein phospahatase nuclear targeting subunit (CAT53 gene).
BC150310 - Homo sapiens cDNA clone IMAGE:8860444.
BC136294 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 10, mRNA (cDNA clone MGC:167904 IMAGE:9020281), complete cds.
BC005267 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 10, mRNA (cDNA clone IMAGE:3683864), partial cds.
AK307406 - Homo sapiens cDNA, FLJ97354.

-  Other Names for This Gene
  Alternate Gene Symbols: CAT53, FB19, NM_002714, NP_002705, O00405, PNUTS, PP1RA_HUMAN, Q96QC0, uc011gte.2
UCSC ID: uc011gte.3
RefSeq Accession: NM_002714
Protein: Q96QC0 (aka PP1RA_HUMAN