Human Gene PPP1R10 (uc011gte.3) Description and Page Index
Description: Homo sapiens protein phosphatase 1, regulatory subunit 10 (PPP1R10), transcript variant 1, mRNA. RefSeq Summary (NM_002714): This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]. Transcript (Including UTRs) Position: chr6_mann_hap4:1,916,249-1,933,156 Size: 16,908 Total Exon Count: 20 Strand: - Coding Region Position: chr6_mann_hap4:1,917,398-1,925,793 Size: 8,396 Coding Exon Count: 18
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Comments and Description Text from UniProtKB
ID:PP1RA_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 1 regulatory subunit 10; AltName: Full=MHC class I region proline-rich protein CAT53; AltName: Full=PP1-binding protein of 114 kDa; AltName: Full=Phosphatase 1 nuclear targeting subunit; AltName: Full=Protein FB19; AltName: Full=p99; FUNCTION: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). SUBUNIT: Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity). SUBCELLULAR LOCATION: Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. PTM: Phosphorylated on Ser-398 and Thr-400 by PKA within the region necessary for interaction with PPP1CA (By similarity). SIMILARITY: Contains 1 C3H1-type zinc finger. SIMILARITY: Contains 1 TFIIS N-terminal domain.
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00642 - Zinc finger C-x8-C-x5-C-x3-H type (and similar)
SCOP Domains: 47676 - Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 90229 - CCCH zinc finger
ModBase Predicted Comparative 3D Structure on Q96QC0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.