Human Gene HLA-E (uc011gst.2) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class I, E (HLA-E), mRNA.
RefSeq Summary (NM_005516): HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB209870.1, BC040479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,805,367-1,810,060 Size: 4,694 Total Exon Count: 7 Strand: +
Coding Region
   Position: chr6_mann_hap4:1,805,394-1,808,436 Size: 3,043 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: HLA-E
CDC HuGE Published Literature: HLA-E
Positive Disease Associations: Behcet Syndrome , bone marrow transplantation , graft-versus-host disease , HIV , nasopharyngeal cancer , Psoriasis
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. bone marrow transplantation
    Tamouza, R. et al. 2005, Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation., Transplantation. 2005 Jul;80(1):140-4. [PubMed 16003246]
  3. graft-versus-host disease
    Tamouza, R. et al. 2006, Homozygous Status for HLA-E*0103 Confers Protection from Acute Graft-Versus-Host Disease and Transplant-Related Mortality in HLA-Matched Sibling Hematopoietic Stem Cell Transplantation, Transplantation 2006 82(11) 1436-1440. [PubMed 17164714]
    These data suggest that the homozygous state for HLA-E*0103 allele behaves as a protective genetic factor against aGVHD and TRM and likely contributes to improved survival in HLA-genoidentical bone marrow transplantation.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.6027-0.170 Picture PostScript Text
3' UTR -514.991459-0.353 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  AK292391 - Homo sapiens cDNA FLJ78238 complete cds, highly similar to Homo sapiens major histocompatibility complex, class I, E, mRNA.
AK098434 - Homo sapiens cDNA FLJ25568 fis, clone JTH03907, highly similar to HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN E E*0101/E*0102 PRECURSOR.
AK316327 - Homo sapiens cDNA, FLJ79226 complete cds, highly similar to HLA class I histocompatibility antigen, alphachain E precursor.
AK300906 - Homo sapiens cDNA FLJ54887 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain E precursor.
AK298695 - Homo sapiens cDNA FLJ55134 complete cds, moderately similar to HLA class I histocompatibility antigen, alpha chain E precursor.
AK314411 - Homo sapiens cDNA, FLJ95191.
AK301125 - Homo sapiens cDNA FLJ53747 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain E precursor.
AK296822 - Homo sapiens cDNA FLJ52681 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain E precursor.
BC040479 - Homo sapiens major histocompatibility complex, class I, E, mRNA (cDNA clone MGC:32811 IMAGE:4696327), complete cds.
AK225048 - Homo sapiens mRNA for HLA class I histocompatibility antigen, alpha chain E precursor variant, clone: adKA03449.
BC002578 - Homo sapiens major histocompatibility complex, class I, E, mRNA (cDNA clone MGC:1408 IMAGE:3140835), complete cds.
M20022 - Human HLA-E class I mRNA.
AB385554 - Synthetic construct DNA, clone: pF1KB5542, Homo sapiens HLA-E gene for major histocompatibility complex, class I, E precursor, complete cds, without stop codon, in Flexi system.
DQ895077 - Synthetic construct Homo sapiens clone IMAGE:100009537; FLH181148.01L; RZPDo839A05135D major histocompatibility complex, class I, E (HLA-E) gene, encodes complete protein.
DQ891891 - Synthetic construct clone IMAGE:100004521; FLH181152.01X; RZPDo839A05136D major histocompatibility complex, class I, E (HLA-E) gene, encodes complete protein.
AJ293263 - Homo sapiens mRNA for MHC class I antigen, HLA-E*01033 allele (HLA-E gene).
AJ293264 - Homo sapiens mRNA for MHC class I antigen, HLA-E*0101 allele (HLA-E gene).
AY216681 - Homo sapiens nonclassical MHC class I antigen (HLA-E) mRNA, HLA-E*010301 allele, complete cds.
AY221103 - Homo sapiens MHC class I antigen (HLA-E) mRNA, HLA-E*010303 variant allele, complete cds.
BC004297 - Homo sapiens, clone IMAGE:3622619, mRNA, partial cds.
AB209870 - Homo sapiens mRNA for HLA class I histocompatibility antigen, E alpha chain precursor variant protein.
M31183 - Homo sapiens (cosmid clone cd3.3) MHC class I HLA-B51 mRNA, 3' end of cds.
L78455 - Homo sapiens isolate SPA 70 HLA-E gene exons 2 and 3.
L78934 - Homo sapiens isolate SPAARN 70 HLA-E gene exons 2 and 3.
BX538084 - Homo sapiens mRNA; cDNA DKFZp686P19218 (from clone DKFZp686P19218).
X56841 - H.sapiens HLA-E gene.
X64879 - H.sapiens mRNA for HLA-E heavy chain (exons 4 - 7).

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04144 - Endocytosis
hsa04514 - Cell adhesion molecules (CAMs)
hsa04612 - Antigen processing and presentation
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04940 - Type I diabetes mellitus
hsa05320 - Autoimmune thyroid disease
hsa05330 - Allograft rejection
hsa05332 - Graft-versus-host disease
hsa05416 - Viral myocarditis

+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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