Human Gene HLA-E (uc011gst.2) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class I, E (HLA-E), mRNA.
RefSeq Summary (NM_005516): HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB209870.1, BC040479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,805,367-1,810,060 Size: 4,694 Total Exon Count: 7 Strand: +
Coding Region
   Position: chr6_mann_hap4:1,805,394-1,808,436 Size: 3,043 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6_mann_hap4:1,805,367-1,810,060)mRNA (may differ from genome)Protein (399 aa)
Gene SorterGenome BrowserProtein FASTATable SchemaBioGPSCGAP
EnsemblExonPrimerGeneCardsGeneNetworkGepis Tissue