Human Gene TRIM26 (uc011gsd.1) Description and Page Index
  Description: Homo sapiens tripartite motif containing 26 (TRIM26), transcript variant 1, mRNA.
RefSeq Summary (NM_003449): The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,514,942-1,521,040 Size: 6,099 Total Exon Count: 3 Strand: -
Coding Region
   Position: chr6_mann_hap4:1,514,942-1,515,379 Size: 438 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: Q5SPU2_HUMAN
DESCRIPTION: SubName: Full=Tripartite motif-containing protein 26; Flags: Fragment;
SIMILARITY: Contains RING-type zinc finger.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: TRIM26
CDC HuGE Published Literature: TRIM26
Positive Disease Associations: Behcet Syndrome , Lupus Erythematosus, Systemic , Multiple Sclerosis , Schizophrenia
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.81249-0.304 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000315 - Znf_B-box
IPR020457 - Znf_B-box_chordata
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF00643 - B-box zinc finger

SCOP Domains:
57845 - B-box zinc-binding domain
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q5SPU2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  BC021115 - Homo sapiens tripartite motif-containing 26, mRNA (cDNA clone IMAGE:5094007), with apparent retained intron.
BC032297 - Homo sapiens tripartite motif-containing 26, mRNA (cDNA clone MGC:40232 IMAGE:4938971), complete cds.
BC024039 - Homo sapiens tripartite motif-containing 26, mRNA (cDNA clone MGC:12710 IMAGE:3954669), complete cds.
U09825 - Human acid finger protein mRNA, complete cds.
AK314782 - Homo sapiens cDNA, FLJ95652.
CU689318 - Synthetic construct Homo sapiens gateway clone IMAGE:100019819 5' read TRIM26 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: BC021115, DAAP-200B17.5-006, DADB-23P23.6-006, DAMA-361I19.5-006, DAMC-72C9.6-006, DAQB-44E15.6-006, DASS-211F20.5-006, Q5SPU2, Q5SPU2_HUMAN
UCSC ID: uc011gsd.1
RefSeq Accession: NM_003449
Protein: Q5SPU2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC021115.1
exon count: 3CDS single in 3' UTR: no RNA size: 1742
ORF size: 438CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 965.00frame shift in genome: no % Coverage: 23.94
has start codon: yes stop codon in genome: no # of Alignments: 8
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.