Human Gene TRIM26 (uc011gsd.1) Description and Page Index
Description: Homo sapiens tripartite motif containing 26 (TRIM26), transcript variant 1, mRNA. RefSeq Summary (NM_003449): The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]. Transcript (Including UTRs) Position: chr6_mann_hap4:1,514,942-1,521,040 Size: 6,099 Total Exon Count: 3 Strand: - Coding Region Position: chr6_mann_hap4:1,514,942-1,515,379 Size: 438 Coding Exon Count: 1
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Comments and Description Text from UniProtKB
ID:Q5SPU2_HUMAN DESCRIPTION: SubName: Full=Tripartite motif-containing protein 26; Flags: Fragment; SIMILARITY: Contains RING-type zinc finger. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5SPU2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.