Human Gene TRIM26 (uc011grz.2) Description and Page Index
  Description: Homo sapiens tripartite motif containing 26 (TRIM26), transcript variant 1, mRNA.
RefSeq Summary (NM_003449): The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,500,731-1,521,040 Size: 20,310 Total Exon Count: 9 Strand: -
Coding Region
   Position: chr6_mann_hap4:1,502,152-1,515,379 Size: 13,228 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: TRI26_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 26; AltName: Full=Acid finger protein; Short=AFP; AltName: Full=RING finger protein 95; AltName: Full=Zinc finger protein 173;
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 RING-type zinc finger.

+  Genetic Association Studies of Complex Diseases and Disorders
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+  Comparative Toxicogenomics Database (CTD)
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+  Microarray Expression Data
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+  mRNA Secondary Structure of 3' and 5' UTRs
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF00622 - SPRY domain
PF00643 - B-box zinc finger

SCOP Domains:
57845 - B-box zinc-binding domain
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q12899
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
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+  Descriptions from all associated GenBank mRNAs
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+  Other Names for This Gene
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+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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