Human Gene PPP1R11 (uc011grl.2) Description and Page Index
  Description: Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 11 (PPP1R11), mRNA.
RefSeq Summary (NM_021959): This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X81003.1, BQ067250.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,333,524-1,336,701 Size: 3,178 Total Exon Count: 3 Strand: +
Coding Region
   Position: chr6_mann_hap4:1,333,781-1,335,676 Size: 1,896 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein phosphatase 1 regulatory subunit 11; AltName: Full=Hemochromatosis candidate gene V protein; Short=HCG V; AltName: Full=Protein phosphatase inhibitor 3;
FUNCTION: Inhibitor of protein phosphatase 1.
INTERACTION: P62139:PPP1CA (xeno); NbExp=2; IntAct=EBI-1048104, EBI-2008988;
TISSUE SPECIFICITY: Widely expressed.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: PPP1R11
CDC HuGE Published Literature: PPP1R11
Positive Disease Associations: Multiple Sclerosis
Related Studies:
  1. Multiple Sclerosis
    Sergio E Baranzini et al. Human molecular genetics 2009, Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis., Human molecular genetics. [PubMed 19010793]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips


GNF Expression Atlas 1 Human Data on Affy U95 Chips


-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -101.47257-0.395 Picture PostScript Text
3' UTR -304.141025-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011107 - PPI_Ypi1

Pfam Domains:
PF07491 - Protein phosphatase inhibitor

ModBase Predicted Comparative 3D Structure on O60927
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     

-  Descriptions from all associated GenBank mRNAs
  AK310593 - Homo sapiens cDNA, FLJ17635.
AK313175 - Homo sapiens cDNA, FLJ93673, Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit11 (PPP1R11), transcript variant 1, mRNA.
X81003 - Homo sapiens HCG V mRNA.
BC102010 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 11, mRNA (cDNA clone MGC:125743 IMAGE:40029469), complete cds.
BC102011 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 11, mRNA (cDNA clone MGC:125742 IMAGE:40029466), complete cds.
BC104750 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 11, mRNA (cDNA clone MGC:125741 IMAGE:40029465), complete cds.
BC003144 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 11, mRNA (cDNA clone MGC:3857 IMAGE:2823116), complete cds.
AF070599 - Homo sapiens clone 24451 mRNA sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: HCGV, NM_021959, NP_068778, O60927, PP1RB_HUMAN, TCTE5
UCSC ID: uc011grl.2
RefSeq Accession: NM_021959
Protein: O60927 (aka PP1RB_HUMAN