Human Gene HLA-A (uc011gqw.2) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class I, A (HLA-A), transcript variant 1, mRNA.
RefSeq Summary (NM_002116): HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,202,632-1,205,459 Size: 2,828 Total Exon Count: 6 Strand: +
Coding Region
   Position: chr6_mann_hap4:1,202,716-1,205,458 Size: 2,743 Coding Exon Count: 6 

Page IndexSequence and LinksGenetic AssociationsCTDMicroarrayRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

+  Genetic Association Studies of Complex Diseases and Disorders
  Press "+" in the title bar above to open this section.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.7084-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Orthologous Genes in Other Species
  Press "+" in the title bar above to open this section.

+  Descriptions from all associated GenBank mRNAs
  Press "+" in the title bar above to open this section.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04144 - Endocytosis
hsa04514 - Cell adhesion molecules (CAMs)
hsa04612 - Antigen processing and presentation
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04940 - Type I diabetes mellitus
hsa05320 - Autoimmune thyroid disease
hsa05330 - Allograft rejection
hsa05332 - Graft-versus-host disease
hsa05416 - Viral myocarditis

BioCarta from NCI Cancer Genome Anatomy Project
h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity
h_ctlPathway - CTL mediated immune response against target cells
h_mhcPathway - Antigen Processing and Presentation

+  Other Names for This Gene
  Press "+" in the title bar above to open this section.

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AF287958.1
exon count: 6CDS single in 3' UTR: no RNA size: 981
ORF size: 975CDS single in intron: no Alignment % ID: 98.27
txCdsPredict score: 1125.00frame shift in genome: no % Coverage: 99.49
has start codon: yes stop codon in genome: no # of Alignments: 8
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

+  Methods, Credits, and Use Restrictions
  Press "+" in the title bar above to open this section.