Human Gene HLA-H (uc011gqo.2) Description and Page Index
Description: Homo sapiens major histocompatibility complex, class I, H (pseudogene) (HLA-H), non-coding RNA. RefSeq Summary (NR_001434): This major histocompatibility complex gene represents a transcribed pseudogene, possibly derived from HLA-A. This gene displays extensive variation. [provided by RefSeq, May 2010]. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support ERS025093 [ECO:0000350] ##Evidence-Data-END## Transcript (Including UTRs) Position: chr6_mann_hap4:1,149,678-1,151,662 Size: 1,985 Total Exon Count: 3 Strand: + Coding Region Position: chr6_mann_hap4:1,149,824-1,151,038 Size: 1,215 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B4DT05
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
M27971 - Human MHC class I HLA-ABC mRNA, 3' end. AK299998 - Homo sapiens cDNA FLJ52667 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain H precursor. AK090500 - Homo sapiens cDNA FLJ33181 fis, clone ADRGL2003684, highly similar to HLA class I histocompatibility antigen, alpha chain H precursor. AX746483 - Sequence 8 from Patent EP1308459. AK308374 - Homo sapiens cDNA, FLJ98322. AK309480 - Homo sapiens cDNA, FLJ99521. AK293556 - Homo sapiens cDNA FLJ53543 complete cds, moderately similar to HLA class I histocompatibility antigen, alpha chain H precursor. AK309163 - Homo sapiens cDNA, FLJ99204. AK300878 - Homo sapiens cDNA FLJ53565 complete cds, moderately similar to HLA class I histocompatibility antigen, alpha chain H precursor.