Human Gene HLA-G (uc011gqm.3) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class I, G (HLA-G), mRNA.
RefSeq Summary (NM_002127): HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC021708.2, X17273.1 [ECO:0000331] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,096,153-1,276,307 Size: 180,155 Total Exon Count: 6 Strand: +
Coding Region
   Position: chr6_mann_hap4:1,096,224-1,098,488 Size: 2,265 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: HLAG_HUMAN
DESCRIPTION: RecName: Full=HLA class I histocompatibility antigen, alpha chain G; AltName: Full=HLA G antigen; AltName: Full=MHC class I antigen G; Flags: Precursor;
FUNCTION: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.
SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Homodimer; disulfide-linked. Binds to LILRB1 and LILRB2.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed in trophoblasts.
SIMILARITY: Belongs to the MHC class I family.
SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HLAGID43744ch6p22.html";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: HLA-G
CDC HuGE Published Literature: HLA-G
Positive Disease Associations: Behcet Syndrome , birth weight; placental weight , Crohn's disease ulcerative colitis , Drug-Induced Liver Injury , HIV , Immunoglobulin E , pre-eclampsia , preeclampsia , pregnancy loss, recurrent , pregnancy loss, recurrent; in vitro fertilization success , sarcoidosis
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.8071-0.363 Picture PostScript Text
3' UTR -122.90450-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like_dom
IPR013783 - Ig-like_fold
IPR003006 - Ig/MHC_CS
IPR003597 - Ig_C1-set
IPR011161 - MHC_I-like_Ag-recog
IPR011162 - MHC_I/II-like_Ag-recog
IPR027648 - MHC_I_a
IPR001039 - MHC_I_a_a1/a2

Pfam Domains:
PF00047 - Immunoglobulin domain
PF00129 - Class I Histocompatibility antigen, domains alpha 1 and 2
PF07654 - Immunoglobulin C1-set domain

SCOP Domains:
48726 - Immunoglobulin
54452 - MHC antigen-recognition domain

Protein Data Bank (PDB) 3-D Structure

1YDP
- X-ray Chimera LS-SNP

2D31
- X-ray Chimera LS-SNP

2DYP
- X-ray Chimera LS-SNP
To conserve bandwidth, only the images from the first 3 structures are shown.
3BZE - X-ray Chimera LS-SNP 3CDG - X-ray Chimera LS-SNP 3CII - X-ray Chimera LS-SNP
3KYN - X-ray Chimera LS-SNP 3KYO - X-ray Chimera LS-SNP
Chimera help

ModBase Predicted Comparative 3D Structure on P17693
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
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-  Descriptions from all associated GenBank mRNAs
  M27971 - Human MHC class I HLA-ABC mRNA, 3' end.
U88244 - Homo sapiens MHC-G (HLA) mRNA, HLA-G*01012 allele, partial cds.
AF071022 - Homo sapiens MHC class I antigen HLA-G mRNA (HLA-G*01013 allele), partial cds.
BC021708 - Homo sapiens major histocompatibility complex, class I, G, mRNA (cDNA clone MGC:26146 IMAGE:4822521), complete cds.
AK302054 - Homo sapiens cDNA FLJ51376 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain G precursor.
AK093478 - Homo sapiens cDNA FLJ36159 fis, clone TESTI2025791, highly similar to HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN G PRECURSOR.
AX748153 - Sequence 1678 from Patent EP1308459.
AF226990 - Homo sapiens MHC class I antigen (HLA-G) mRNA, HLA-G1 allele, complete cds.
AB528641 - Synthetic construct DNA, clone: pF1KB6430, Homo sapiens HLA-G gene for major histocompatibility complex, class I, G, without stop codon, in Flexi system.
X17273 - Human HLA G (HLA 6.0) mRNA for non classical class I transplantation antigen.
AY359818 - Homo sapiens MHC class I antigen (HLA-G) mRNA, complete cds.
DQ896809 - Synthetic construct Homo sapiens clone IMAGE:100011269; FLH166785.01L; RZPDo839D0487D HLA-G histocompatibility antigen, class I, G (HLA-G) gene, encodes complete protein.
EU176192 - Synthetic construct Homo sapiens clone IMAGE:100006591; FLH263919.01X; RZPDo839A10246D HLA-G histocompatibility antigen, class I, G (HLA-G) gene, encodes complete protein.
AF196177 - Homo sapiens nonfunctional MHC class I antigen isoform G1 (HLA-G) mRNA, HLA-G*0105N allele, complete sequence, alternatively spliced.
AF196178 - Homo sapiens nonfunctional MHC class I antigen isoform G5 (HLA-G) mRNA, HLA-G*0105N allele, complete sequence, alternatively spliced.
M90683 - Homo sapiens b2 microglobulin (HLA-G) mRNA, complete cds.
M90684 - Human lymphocyte antigen (HLA-G2.1) mRNA, complete cds.
M90685 - Human lymphocyte antigen (HLA-G2.2) mRNA, complete cds.
M90686 - Human lymphocyte antigen (HLA-G3) mRNA, complete cds.
M32800 - Human MHC class I truncated HLA G mRNA, complete cds.
AF436089 - Homo sapiens MHC class I antigen (HLA-G) mRNA, HLA-G*01041 allele, partial cds.
U58024 - Human lymphocyte antigen G (HLA-G) mRNA, partial cds, clone CEPH-G1.
U58025 - Human lymphocyte antigen G (HLA-G) mRNA, partial cds, clone CEPH-G2.
U58026 - Human lymphocyte antigen G (HLA-G) mRNA, partial cds, clone CEPH-G4.
U58027 - Human lymphocyte antigen G (HLA-G) mRNA, partial cds, clone CEPH-G5.
U58028 - Human lymphocyte antigen G (HLA-G) mRNA, partial cds, clone CEPH-G6.
U58029 - Human lymphocyte antigen G (HLA-G) mRNA, partial cds, clone CEPH-G7.
U58094 - Human lymphocyte antigen G (HLA-G) mRNA, partial cds, clone CEPH-G3.
AF071020 - Homo sapiens clone 19 MHC class I antigen (HLA-G) mRNA, partial cds.
AF071017 - Homo sapiens MHC class I antigen HLA-G mRNA (HLA-G*01013 allele), partial cds.
AF071018 - Homo sapiens MHC class I antigen HLA-G mRNA (HLA-G*0104 allele), partial cds.
AF071019 - Homo sapiens clone 18 MHC class I antigen (HLA-G) mRNA, partial cds.
AF071021 - Homo sapiens MHC class I antigen HLA-G mRNA (HLA-G*01012 allele), partial cds.
DQ600446 - Homo sapiens piRNA piR-38512, complete sequence.
DQ580344 - Homo sapiens piRNA piR-48456, complete sequence.
M27539 - Human MHC class I HLA-A cell surface antigen mRNA, (HLA-A28,-B40, -Cw3), clone LB45.
BC089454 - Homo sapiens major histocompatibility complex, class I, J (pseudogene), mRNA (cDNA clone IMAGE:30563285).
BC020891 - Homo sapiens major histocompatibility complex, class I, J (pseudogene), mRNA (cDNA clone IMAGE:4694038).
BC062324 - Homo sapiens major histocompatibility complex, class I, J (pseudogene), mRNA (cDNA clone IMAGE:5420082).

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04144 - Endocytosis
hsa04514 - Cell adhesion molecules (CAMs)
hsa04612 - Antigen processing and presentation
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04940 - Type I diabetes mellitus
hsa05320 - Autoimmune thyroid disease
hsa05330 - Allograft rejection
hsa05332 - Graft-versus-host disease
hsa05416 - Viral myocarditis

-  Other Names for This Gene
  Alternate Gene Symbols: HLA-6.0, HLAG, HLAG_HUMAN, NM_002127, NP_002118, P17693, U88244, uc011gqm.2
UCSC ID: uc011gqm.3
RefSeq Accession: NM_002127
Protein: P17693 (aka HLAG_HUMAN