Human Gene HLA-F (uc011gpw.1) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class I, F (HLA-F), transcript variant 1, mRNA.
RefSeq Summary (NM_018950): This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:991,622-997,613 Size: 5,992 Total Exon Count: 8 Strand: +
Coding Region
   Position: chr6_mann_hap4:991,746-996,390 Size: 4,645 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: HLA-F
CDC HuGE Published Literature: HLA-F
Positive Disease Associations: Behcet Syndrome
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]

+  Comparative Toxicogenomics Database (CTD)
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-  Microarray Expression Data
 
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GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK096962 - Homo sapiens cDNA FLJ39643 fis, clone SMINT2004023, highly similar to HLA class I histocompatibility antigen, alphachain F precursor.
X13112 - Human partial mRNA for MHC class I antigen HLA-A11K.
AK300090 - Homo sapiens cDNA FLJ60056 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain F precursor.
AK302420 - Homo sapiens cDNA FLJ53112 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain F precursor.
BC009260 - Homo sapiens major histocompatibility complex, class I, F, mRNA (cDNA clone IMAGE:4039990), partial cds.
AK309156 - Homo sapiens cDNA, FLJ99197.
AK303670 - Homo sapiens cDNA FLJ53123 complete cds.
AK298704 - Homo sapiens cDNA FLJ60325 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain F precursor.
AK125274 - Homo sapiens cDNA FLJ43284 fis, clone LYMPB2000083, highly similar to HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN F PRECURSOR.
AK225185 - Homo sapiens mRNA for major histocompatibility complex, class I, F precursor variant, clone: COL01957.
AK301488 - Homo sapiens cDNA FLJ54780 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain F precursor.
BC062991 - Homo sapiens major histocompatibility complex, class I, F, mRNA (cDNA clone MGC:74962 IMAGE:5496696), complete cds.
CU687616 - Synthetic construct Homo sapiens gateway clone IMAGE:100021717 5' read HLA-F mRNA.
AB590981 - Synthetic construct DNA, clone: pFN21AE1907, Homo sapiens HLA-F gene for major histocompatibility complex, class I, F, without stop codon, in Flexi system.
AY253269 - Homo sapiens MHC class Ib antigen (HLA-F) mRNA, HLA-F*0101 variant 1 allele, complete cds.
AY253270 - Homo sapiens MHC class Ib antigen (HLA-F) mRNA, HLA-F*0101 variant 2 allele, complete cds.
AY253271 - Homo sapiens MHC class Ib antigen (HLA-F) mRNA, HLA-F*0101 variant 3 allele, complete cds.
DQ367723 - Homo sapiens MHC class I antigen (HLA-F) mRNA, complete cds.
GQ891552 - Homo sapiens MHC class I antigen (HLA-F) mRNA, HLA-F*0109 allele, complete cds.
AY216682 - Homo sapiens nonclassical MHC class I antigen (HLA-F) mRNA, HLA-F*0101 variant allele, partial cds.
AY221102 - Homo sapiens MHC class I antigen (HLA-F) mRNA, partial cds.

+  Biochemical and Signaling Pathways
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+  Other Names for This Gene
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-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK298704.1
exon count: 8CDS single in 3' UTR: no RNA size: 1533
ORF size: 1308CDS single in intron: no Alignment % ID: 99.87
txCdsPredict score: 2741.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 7
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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