Human Gene MOG (uc011gph.2) Description and Page Index
  Description: Homo sapiens myelin oligodendrocyte glycoprotein (MOG), transcript variant alpha6, mRNA.
RefSeq Summary (NM_001170418): The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:927,718-943,106 Size: 15,389 Total Exon Count: 7 Strand: +
Coding Region
   Position: chr6_mann_hap4:927,947-941,919 Size: 13,973 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: MOG_HUMAN
DESCRIPTION: RecName: Full=Myelin-oligodendrocyte glycoprotein; Flags: Precursor;
FUNCTION: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication.
SUBUNIT: Homodimer (By similarity). May form heterodimers between the different isoforms.
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Multi-pass membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 5: Cell membrane; Multi-pass membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 6: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 7: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 8: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 9: Cell membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
DISEASE: Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye- movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=The disease is caused by mutations affecting the gene represented in this entry.
SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
CAUTION: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).
WEB RESOURCE: Name=Wikipedia; Note=Myelin oligodendrocyte glycoprotein entry; URL="http://en.wikipedia.org/wiki/Myelin_oligodendrocyte_glycoprotein";

+  Genetic Association Studies of Complex Diseases and Disorders
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+  Comparative Toxicogenomics Database (CTD)
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+  Microarray Expression Data
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+  mRNA Secondary Structure of 3' and 5' UTRs
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like_dom
IPR013783 - Ig-like_fold
IPR013106 - Ig_V-set
IPR003596 - Ig_V-set_subgr
IPR016663 - Myelin-oligodendrocyte_glycop

Protein Data Bank (PDB) 3-D Structure

1Q70
- Model Chimera
Chimera help

ModBase Predicted Comparative 3D Structure on Q16653
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
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Protein Sequence     
Alignment     

+  Descriptions from all associated GenBank mRNAs
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+  Other Names for This Gene
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+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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