Human Gene MOG (uc011gph.2) Description and Page Index
  Description: Homo sapiens myelin oligodendrocyte glycoprotein (MOG), transcript variant alpha6, mRNA.
RefSeq Summary (NM_001170418): The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:927,718-943,106 Size: 15,389 Total Exon Count: 7 Strand: +
Coding Region
   Position: chr6_mann_hap4:927,947-941,919 Size: 13,973 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: MOG_HUMAN
DESCRIPTION: RecName: Full=Myelin-oligodendrocyte glycoprotein; Flags: Precursor;
FUNCTION: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication.
SUBUNIT: Homodimer (By similarity). May form heterodimers between the different isoforms.
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Multi-pass membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 5: Cell membrane; Multi-pass membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 6: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 7: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 8: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 9: Cell membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
DISEASE: Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye- movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=The disease is caused by mutations affecting the gene represented in this entry.
SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
CAUTION: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).
WEB RESOURCE: Name=Wikipedia; Note=Myelin oligodendrocyte glycoprotein entry; URL="http://en.wikipedia.org/wiki/Myelin_oligodendrocyte_glycoprotein";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: MOG
CDC HuGE Published Literature: MOG
Positive Disease Associations: Behcet Syndrome
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -93.50229-0.408 Picture PostScript Text
3' UTR -373.731187-0.315 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like_dom
IPR013783 - Ig-like_fold
IPR013106 - Ig_V-set
IPR003596 - Ig_V-set_subgr
IPR016663 - Myelin-oligodendrocyte_glycop

Protein Data Bank (PDB) 3-D Structure

1Q70
- Model Chimera
Chimera help

ModBase Predicted Comparative 3D Structure on Q16653
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AK308949 - Homo sapiens cDNA, FLJ98990.
AB209815 - Homo sapiens mRNA for myelin oligodendrocyte glycoprotein isoform alpha1 precursor variant protein.
U64564 - Human myelin/oligodendrocyte glycoprotein-25.1kD (Mog) mRNA, complete cds.
BC035938 - Homo sapiens myelin oligodendrocyte glycoprotein, mRNA (cDNA clone MGC:26137 IMAGE:4791512), complete cds.
AK312892 - Homo sapiens cDNA, FLJ93336, highly similar to Homo sapiens myelin oligodendrocyte glycoprotein (MOG), mRNA.
AK295213 - Homo sapiens cDNA FLJ51848 complete cds, highly similar to Myelin-oligodendrocyte glycoprotein precursor.
U18798 - Human myelin/oligodendrocyte glycoprotein MOG alpha 1 isoform (MOG) mRNA, complete cds.
U18799 - Human myelin/oligodendrocyte glycoprotein MOG alpha 2 isoform (MOG) mRNA, complete cds.
U18843 - Human myelin/oligodendrocyte glycoprotein MOG alpha 3 isoform (MOG) mRNA, complete cds.
DQ895585 - Synthetic construct Homo sapiens clone IMAGE:100010045; FLH263697.01L; RZPDo839E01147D myelin oligodendrocyte glycoprotein (MOG) gene, encodes complete protein.
DQ895586 - Synthetic construct Homo sapiens clone IMAGE:100010046; FLH185707.01L; RZPDo839E02147D myelin oligodendrocyte glycoprotein (MOG) gene, encodes complete protein.
EU176510 - Synthetic construct Homo sapiens clone IMAGE:100011651; FLH264074.01L; RZPDo839F02257D myelin oligodendrocyte glycoprotein (MOG) gene, encodes complete protein.
DQ892374 - Synthetic construct clone IMAGE:100005004; FLH185711.01X; RZPDo839E02148D myelin oligodendrocyte glycoprotein (MOG) gene, encodes complete protein.
U18800 - Homo sapiens myelin/oligodendrocyte glycoprotein alpha 4 isoform (MOG) mRNA, complete cds, alternatively spliced.
X74511 - H.sapiens mRNA for myelin oligodendrocyte glycoprotein.
AY566852 - Homo sapiens MOG beta-1 mRNA, complete cds, alternatively spliced.
U18801 - Human myelin/oligodendrocyte glycoprotein MOG beta 1 isoform (MOG) mRNA, complete cds.
U18803 - Human myelin/oligodendrocyte glycoprotein MOG beta 2 isoform (MOG) mRNA, complete cds.
U18840 - Human myelin/oligodendrocyte glycoprotein MOG beta 3 isoform (MOG) mRNA, complete cds.
AY566851 - Homo sapiens MOG IG-2' mRNA, partial cds, alternatively spliced.
AY566849 - Homo sapiens MOG AluA mRNA, partial cds, alternatively spliced.
AY566848 - Homo sapiens MOG Ig-AluB mRNA, partial cds, alternatively spliced.
AY566850 - Homo sapiens MOG AluB mRNA, partial cds, alternatively spliced.
AY566846 - Homo sapiens MOG alpha-5 mRNA, partial cds, alternatively spliced.
AY566847 - Homo sapiens MOG alpha-6 mRNA, partial cds, alternatively spliced.
AY566853 - Homo sapiens MOG beta-2 mRNA, partial cds, alternatively spliced.
AY566854 - Homo sapiens MOG beta-3 mRNA, partial cds, alternatively spliced.
U64565 - Human myelin/oligodendrocyte glycoprotein-25.6kD (Mog) mRNA, partial cds.
U64566 - Human myelin/oligodendrocyte glycoprotein-22.7kD (Mog) mRNA, partial cds.
U64567 - Human myelin/oligodendrocyte glycoprotein-21.0kD (Mog) mRNA, partial cds.
U64568 - Human myelin/oligodendrocyte glycoprotein-20.5kD (Mog) mRNA, partial cds.
U64569 - Human myelin/oligodendrocyte glycoprotein-20.2kD (Mog) mRNA, partial cds.
U64570 - Human myelin/oligodendrocyte glycoprotein-16.3kD(a) (Mog) mRNA, partial cds.
U64571 - Human myelin/oligodendrocyte glycoprotein-16.3kD(b) (Mog) mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PGF0, E9PGF0_HUMAN, NM_001170418, NP_001163889
UCSC ID: uc011gph.2
RefSeq Accession: NM_001170418
Protein: Q16653 (aka MOG_HUMAN