Human Gene MOG (uc011gpa.2) Description and Page Index
  Description: Homo sapiens myelin oligodendrocyte glycoprotein (MOG), transcript variant beta2, mRNA.
RefSeq Summary (NM_001008229): The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:927,718-935,468 Size: 7,751 Total Exon Count: 3 Strand: +
Coding Region
   Position: chr6_mann_hap4:927,947-935,468 Size: 7,522 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

+  Comments and Description Text from UniProtKB
  Press "+" in the title bar above to open this section.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: MOG
CDC HuGE Published Literature: MOG
Positive Disease Associations: Behcet Syndrome
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]

+  Comparative Toxicogenomics Database (CTD)
  Press "+" in the title bar above to open this section.

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
Ratios
      
      
      
     
    
     
Absolute
      
       
      
      
     
    
Ratios
      
       
      
      
     
    
Absolute
   
     
     
Ratios
   
     
     
Absolute

GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
Ratios
      
    
     
      
    
    
Absolute
      
      
      
Ratios
      
      
      
Absolute

+  mRNA Secondary Structure of 3' and 5' UTRs
  Press "+" in the title bar above to open this section.

+  Protein Domain and Structure Information
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AK308949 - Homo sapiens cDNA, FLJ98990.
AB209815 - Homo sapiens mRNA for myelin oligodendrocyte glycoprotein isoform alpha1 precursor variant protein.
U64564 - Human myelin/oligodendrocyte glycoprotein-25.1kD (Mog) mRNA, complete cds.
BC035938 - Homo sapiens myelin oligodendrocyte glycoprotein, mRNA (cDNA clone MGC:26137 IMAGE:4791512), complete cds.
AK312892 - Homo sapiens cDNA, FLJ93336, highly similar to Homo sapiens myelin oligodendrocyte glycoprotein (MOG), mRNA.
AK295213 - Homo sapiens cDNA FLJ51848 complete cds, highly similar to Myelin-oligodendrocyte glycoprotein precursor.
U18798 - Human myelin/oligodendrocyte glycoprotein MOG alpha 1 isoform (MOG) mRNA, complete cds.
U18799 - Human myelin/oligodendrocyte glycoprotein MOG alpha 2 isoform (MOG) mRNA, complete cds.
U18843 - Human myelin/oligodendrocyte glycoprotein MOG alpha 3 isoform (MOG) mRNA, complete cds.
DQ895585 - Synthetic construct Homo sapiens clone IMAGE:100010045; FLH263697.01L; RZPDo839E01147D myelin oligodendrocyte glycoprotein (MOG) gene, encodes complete protein.
DQ895586 - Synthetic construct Homo sapiens clone IMAGE:100010046; FLH185707.01L; RZPDo839E02147D myelin oligodendrocyte glycoprotein (MOG) gene, encodes complete protein.
EU176510 - Synthetic construct Homo sapiens clone IMAGE:100011651; FLH264074.01L; RZPDo839F02257D myelin oligodendrocyte glycoprotein (MOG) gene, encodes complete protein.
DQ892374 - Synthetic construct clone IMAGE:100005004; FLH185711.01X; RZPDo839E02148D myelin oligodendrocyte glycoprotein (MOG) gene, encodes complete protein.
U18800 - Homo sapiens myelin/oligodendrocyte glycoprotein alpha 4 isoform (MOG) mRNA, complete cds, alternatively spliced.
X74511 - H.sapiens mRNA for myelin oligodendrocyte glycoprotein.
AY566852 - Homo sapiens MOG beta-1 mRNA, complete cds, alternatively spliced.
U18801 - Human myelin/oligodendrocyte glycoprotein MOG beta 1 isoform (MOG) mRNA, complete cds.
U18803 - Human myelin/oligodendrocyte glycoprotein MOG beta 2 isoform (MOG) mRNA, complete cds.
U18840 - Human myelin/oligodendrocyte glycoprotein MOG beta 3 isoform (MOG) mRNA, complete cds.
AY566851 - Homo sapiens MOG IG-2' mRNA, partial cds, alternatively spliced.
AY566849 - Homo sapiens MOG AluA mRNA, partial cds, alternatively spliced.
AY566848 - Homo sapiens MOG Ig-AluB mRNA, partial cds, alternatively spliced.
AY566850 - Homo sapiens MOG AluB mRNA, partial cds, alternatively spliced.
AY566846 - Homo sapiens MOG alpha-5 mRNA, partial cds, alternatively spliced.
AY566847 - Homo sapiens MOG alpha-6 mRNA, partial cds, alternatively spliced.
AY566853 - Homo sapiens MOG beta-2 mRNA, partial cds, alternatively spliced.
AY566854 - Homo sapiens MOG beta-3 mRNA, partial cds, alternatively spliced.
U64565 - Human myelin/oligodendrocyte glycoprotein-25.6kD (Mog) mRNA, partial cds.
U64566 - Human myelin/oligodendrocyte glycoprotein-22.7kD (Mog) mRNA, partial cds.
U64567 - Human myelin/oligodendrocyte glycoprotein-21.0kD (Mog) mRNA, partial cds.
U64568 - Human myelin/oligodendrocyte glycoprotein-20.5kD (Mog) mRNA, partial cds.
U64569 - Human myelin/oligodendrocyte glycoprotein-20.2kD (Mog) mRNA, partial cds.
U64570 - Human myelin/oligodendrocyte glycoprotein-16.3kD(a) (Mog) mRNA, partial cds.
U64571 - Human myelin/oligodendrocyte glycoprotein-16.3kD(b) (Mog) mRNA, partial cds.

+  Other Names for This Gene
  Press "+" in the title bar above to open this section.

+  Gene Model Information
  Press "+" in the title bar above to open this section.

+  Methods, Credits, and Use Restrictions
  Press "+" in the title bar above to open this section.