Human Gene UBD (uc011gor.2) Description and Page Index
  Description: Homo sapiens ubiquitin D (UBD), mRNA.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:826,391-830,705 Size: 4,315 Total Exon Count: 2 Strand: -
Coding Region
   Position: chr6_mann_hap4:826,659-830,481 Size: 3,823 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: UBD_HUMAN
DESCRIPTION: RecName: Full=Ubiquitin D; AltName: Full=Diubiquitin; AltName: Full=Ubiquitin-like protein FAT10;
FUNCTION: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)- associated nephropathy (HIVAN).
SUBUNIT: Interact directly with the 26S proteasome. The interaction with NUB1L vie the N-terminal ubiquitin domain facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates its own degradation and that of its conjugates. Interacts with the spindle checkpoint protein MAD2L1 during mitosis. Present in aggresomes of proteasome inhibited cells. Interacts with HDAC6 under proteasome impairment conditions. Forms a thioester with UBA6 in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg).
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Note=Accumulates in aggresomes under proteasome inhibition conditions.
TISSUE SPECIFICITY: Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland.
INDUCTION: Rapidly degraded by the proteasome. Cell-cycle regulation with highest expression during the S-phase (at protein level). Induced during dendritic cell maturation. Negatively regulated by p53/TP53. High levels in various gastrointestinal and gynecological cancer cells. Induced in RTECs in common renal diseases including diabetic nephropathy (DN), IgA nephropathy (IgAN), and hypertensive nephrosclerosis (HN), as well as in hepatocellular carcinoma (HCC) and during HIVAN. Inducible by the proinflammatory cytokines IFNG/IFN-gamma and TNF in cancers of liver and colon. Repressed by NUB1L (at protein level).
PTM: Can be acetylated.
MISCELLANEOUS: Common types of chronic kidney disease are associated with tubulointerstitial up-regulation of FAT10. FAT10 may mediate NF-kappa-B activation and may promote tubulointerstitial inflammation in chronic kidney diseases.
SIMILARITY: Contains 2 ubiquitin-like domains.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/UBDID43742ch6p22.html";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: UBD
CDC HuGE Published Literature: UBD
Positive Disease Associations: Behcet Syndrome
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
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GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.30224-0.238 Picture PostScript Text
3' UTR -62.70268-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019956 - Ubiquitin
IPR000626 - Ubiquitin_dom

Pfam Domains:
PF00240 - Ubiquitin family

SCOP Domains:
54236 - Ubiquitin-like

ModBase Predicted Comparative 3D Structure on O15205
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  Y12653 - H.sapiens mRNA for diubiquitin.
BC012472 - Homo sapiens ubiquitin D, mRNA (cDNA clone MGC:21200 IMAGE:4517233), complete cds.
AF123050 - Homo sapiens ubiquitin-like protein FAT10 (FAT10) mRNA, complete cds.
BC051463 - Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1, mRNA (cDNA clone IMAGE:5299098), **** WARNING: chimeric clone ****.
AK311914 - Homo sapiens cDNA, FLJ92181, highly similar to Homo sapiens ubiquitin D (UBD), mRNA.
CU680336 - Synthetic construct Homo sapiens gateway clone IMAGE:100017948 5' read UBD mRNA.
DQ894624 - Synthetic construct Homo sapiens clone IMAGE:100009084; FLH177018.01L; RZPDo839C02123D ubiquitin D (UBD) gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: B0UZT6, FAT10, NM_006398, NP_006389, O15205, Q5STL2, Q5SUK2, Q96EC7, UBD_HUMAN
UCSC ID: uc011gor.2
RefSeq Accession: NM_006398
Protein: O15205 (aka UBD_HUMAN