Human Gene TNFRSF11B (uc003yon.4) Description and Page Index
  Description: Homo sapiens tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B), mRNA.
RefSeq Summary (NM_002546): The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223155.1, BC030155.2 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025087 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:9571159) ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: chr8:119,935,796-119,964,383 Size: 28,588 Total Exon Count: 5 Strand: -
Coding Region
   Position: chr8:119,936,613-119,964,060 Size: 27,448 Coding Exon Count: 5 

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Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:119,935,796-119,964,383)mRNA (may differ from genome)Protein (401 aa)
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