Human Gene RUNX1T1 (uc003yff.1) Description and Page Index
  Description: Homo sapiens runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 4, mRNA.
RefSeq Summary (NM_004349): This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].
Transcript (Including UTRs)
   Position: chr8:93,016,650-93,029,908 Size: 13,259 Total Exon Count: 4 Strand: -
Coding Region
   Position: chr8:93,017,340-93,029,568 Size: 12,229 Coding Exon Count: 4 

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Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:93,016,650-93,029,908)mRNA (may differ from genome)Protein (210 aa)
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Gepis TissueH-INV