Human Gene COPS5 (uc003xxe.3) Description and Page Index
  Description: Homo sapiens COP9 signalosome subunit 5 (COPS5), mRNA.
RefSeq Summary (NM_006837): The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001187.1, U70734.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr8:67,955,315-67,974,562 Size: 19,248 Total Exon Count: 8 Strand: -
Coding Region
   Position: chr8:67,955,468-67,974,231 Size: 18,764 Coding Exon Count: 8 

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RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:67,955,315-67,974,562)mRNA (may differ from genome)Protein (334 aa)
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