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DNA shape analysis has been established in recent years as an approach that reveals protein-DNA binding specificity determinants beyond nucleotide sequence.
GBshape provides DNA shape annotations of entire genomes.
The database currently contains annotations for minor groove width (MGW), propeller twist (ProT), Roll, helix twist (HelT),
and hydroxyl radical cleavage (ORChID2) for 94 organisms.
Additional genomes can easily be added in the provided framework.
GBshape contains two major tools, a Genome Browser and
a Table Browser.
The Genome Browser provides a graphical representation of DNA shape annotations along standard genome browser annotations (Figure).
The Table Browser enables the data manipulation, downloads, and basic statistical analyses.
The DNA shape annotations were derived with a high-throughput method for DNA shape predictions (DNAshape) and
constitute the whole-genome complement to a motif database of transcription factor binding sites (TFBSshape).
** Please cite any data retrieved from this web server as:
T.P. Chiu, L. Yang, T. Zhou, B.J. Main, S.C. Parker, S.V. Nuzhdin, T.D. Tullius, R. Rohs: GBshape: a genome browser database for DNA shape annotations.
Nucleic Acids Res. 43, D103-D109 (2015)
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